TABLE 1

Wild-type recombinant NAT1 and NAT2 enzyme kinetic parameters for acetylation of para-aminobenzoic acid, sulfadiazine, and sulfamethazine


Enzyme

Substrate

Vmax

Km
nmol/min/mg μM
NAT1*3# PABA 6.4 687
NAT1*3 Sulfadiazine 18.3 5.8
NAT2*4# SMZ 0.8 136
NAT2*4
Sulfadiazine
2.98
5.4
  • # We used exactly the same source of cloned NAT enzyme, within a similar time frame as reported by Palamanda et al. (1995).