TABLE 1

Summary of ethyl-labeled urethane (U) disposition 24 h after 10 or 100 mg/kg administration by gavage Values are presented as cumulative percentage of dose and are the mean ± S.E. of three to eight mice.

[Ethyl-1-14C]U
100 mg/kg
10 mg/kg
CYP2E1+/+
CYP2E1-/-
CYP2E1+/+
CYP2E1-/-
CO2 87.5 ± 2.9 38.0 ± 2.2a 78.5 ± 3.6 30.0 ± 4.2a
Organic volatiles 0.7 ± 0.1 3.0 ± 0.5a 0.6 ± 0.5 4.2 ± 0.4a
Urine 3.1 ± 0.5 4.7 ± 0.8 3.7 ± 0.3 3.2 ± 0.6
Feces Neg Neg Neg Neg
Total percentage of dose
91.3
45.7
82.8
37.4

  • Neg, neglible; value was less than 1%.

  • ↵ a CYP2E1-/- values that are statistically different from corresponding CYP2E1+/+ values (P ≤ 0.05)