TABLE 4

Rate constants (mean ± S.D., n = 3–4/group) governing the disposition of acetaminophen sulfate obtained from compartmental pharmacokinetic analysis of IPL data Nonlinear least-squares regression analysis was performed as described under Materials and Methods using differential equations (eqs. 1, 2, 3, 4) based on the model scheme presented in Fig. 1.

	Wild-Type Wistar Rat IPLs			Mrp2-Deficient (TR^-) Wistar Rat IPLs
	Control	GF120918	Control	GF120918
	h^-1			h^-1
k _S	0.6 ± 0.2	0.36 ± 0.09	1.5 ± 0.3^*	1.2 ± 0.5^*
k _PAS	2.3 ± 0.9	2.5 ± 0.8	1.8 ± 0.8	1.8 ± 0.4
k _BAS	0.2 ± 0.1	0.12 ± 0.05	0.02 ± 0.01^*	0.010 ± 0.003^*

↵* P < 0.05, comparison of TR^- to wild-type within GF120918 treatment group
↵† P < 0.05, comparison of GF120918 to control within rat type