TABLE 1

Amounts of temocapril and temocaprilat in each compartment after apical-to-basolateral transport of temocapril for 2 h through a Caco-2 monolayer After 2 h of apical-to-basolateral transport experiment of temocapril, the amounts of temocapril and temoaprilat in apical and basolateral compartments were determined. Values are mean ± S.D. (n = 3).


Compound

Amount Present
AP Side
BL Side
nmol
Temocapril 97.1 ± 10.0 0.59 ± 0.38
Temocaprilat
50.0 ± 6.00
7.94 ± 0.40