Summary of the regulation of mouse biotransformation enzymes and Oatps in liver after treatment with prototypical activators of transcription factor signaling pathways
AhR Ligands | CAR Activators | PXR Ligands | PPARα Ligands | Nrf2 Activators | |
|---|---|---|---|---|---|
| Cyp1A1 | +(3/3) | 0 | 0 | 0 | 0 |
| Cyp2B10 | 0 | +(3/3) | 0 | 0 | 0 |
| Cyp3A11 | +(2/3) | +(3/3) | +(3/3) | 0 | +(3/3) |
| Cyp4A14 | 0 | 0 | 0 | +(3/3) | 0 |
| Nqo1 | +(3/3) | +(2/3) | 0 | 0 | +(3/3) |
| Oatp1a1 | -(2/3) | -(3/3) | -(3/3) | -(3/3) | -(2/3) |
| Oatp1a4 | 0 | 0 | +(2/3) | 0 | 0 |
| Oatp1a5 | 0 | -(2/3) | -(2/3) | 0 | 0 |
| Oatp1a6 | 0 | 0 | 0 | -(2/3) | 0 |
| Oatp1b2 | 0 | 0 | 0 | 0 | 0 |
| Oatp1c1 | 0 | 0 | 0 | 0 | 0 |
| Oatp2a1 | 0 | 0 | -(3/3) | -(3/3) | 0 |
| Oatp2b1 | +(2/3) | 0 | -(2/3) | -(3/3) | +(2/3) |
| Oatp3a1 | +(3/3) | 0 | -(3/3) | 0 | 0 |
| Oatp4a1 | 0 | 0 | 0 | 0 | 0 |
+ indicates up-regulation of mouse Oatp mRNA expression; — indicates down-regulation of mouse Oatp mRNA expression; 0 indicates no effects on mouse Oatp mRNA expression; 2/3 indicates 2 ligands have effects of the 3 ligands in a transcription pathway.