TABLE 5

Comparison of the prediction performance in humans obtained from different combinations of animal species based on Monte Carlo simulations with 100% CV random error and 100 trials

Species
CLpredicted Mean
CLpredicted Median
PE Mean
m, r, b, k, d 957 736 131
m, r, b, k 1200 771 207
m, r, b, d 1145 663 191
m, b, k, d 1162 766 150
m, r, k, d 1082 680 175
r, b, k, d 1706 791 243
m, r, b 3298 810 821
m, r, k 1811 595 413
m, r, d 1983 803 339
m, b, k 1229 632 204
m, b, d 1122 732 152
m, k, d 1231 865 157
r, b, k 2922 864 536
r, b, d 1292 735 215
r, k, d 1831 826 269
b, k, d 9002 558 1987
m, r 6 × 105 547 7 × 105
m, b 2009 833 362
m, k 1908 646 392
m, d 1819 889 282
r, b 13,677 907 2463
r, k 2355 944 543
r, d 2067 641 370
b, k 9 × 105 791 2 × 105
b, d 20,233 722 5213
k, d
4 × 106
590
3 × 106

  • m, mouse; r, rat; b, rabbit; k, monkey; d, dog.