EC50 values of selected dihydropyridines for increasing mitoxantrone accumulation in MCF-7/MX100 and H460/MX20 cells The EC50 values of compounds for increasing mitoxantrone accumulation in MCF-7/MX100 and H460/MX20 cells were obtained by fitting the fraction of maximal increase to a Hill equation using the computer program WinNonlin (Pharsight), as described under Materials and Methods. The data are expressed as mean ± S.D. from three independent experiments.
Compound | EC50 | ||
|---|---|---|---|
| MCF-7/MX100 | H460/MX20 | ||
| μM | |||
| Nicardipine | 6.97 ± 1.25 | 7.81 ± 0.96 | |
| Niguldipine | 9.82 ± 1.39 | 6.16 ± 1.16 | |
| Nitrendipine | 22.1 ± 10.2 | 21.1 ± 10.5 | |
| Im | 3.71 ± 0.85 | 4.28 ± 0.61 | |
| IIb | 3.80 ± 0.64 | 3.56 ± 0.86 | |