TABLE 4

Human hepatocyte data concordance across different laboratories for dataset studied

Compound	Chemical Class	Log D_7.4/P	fu_inc	CL_{int, in vitro}
								+FCS			-FCS
								Lab 1^a	Lab 2	Lab 3	Lab 4	Lab 5	Lab 6^b
				μl/min/10⁶ cells			μl/min/10⁶ cells
Antipyrine	N	0.23	0.95	0.04	0.1	0.47			0.03
Bosentan	A	-0.37	0.97	0.22	0.2
Caffeine	N	-0.07	0.96	0.13	0.1	1.5			0.2
Diazepam	N	2.89	0.63	0.69	0.7	1.4	1.32		3.85
Diclofenac	A	1.09	0.90					150	256.7
Diltiazem	B	2.8	0.65	1.62	1.9	4.7	23.35	9.0
Furosemide	A	-0.61	0.98			0		2.2
Ibuprofen	A	0.98	0.91			4.2		24.1
Imipramine	B	4.44	0.29			8.2			8.92
Lorazepam	N	2.4	0.73	0.28	0.3	0.27
Metoprolol	B	1.88	0.81					7.0	1.70
Midazolam	N	3.27	0.54	4.49	4.5	7
Moferatone	N	8	0.02	1.83	2
Naloxone	B	2.09	0.78	16.5	16.7	28			47.4
Oxazepam	N	2.24	0.75	0.37	0.37	2
Propranolol	B	1.6	0.85	4.24	4.2	10		10.0	18.54
Theophylline	N	-0.14	0.97	0.11	0.1	0.52
Tolbutamide	A	2.34	0.74			1.6		2.4
Tolcapone	A	2.7	0.67	1.1	1.2
Verapamil	B	3.79	0.42			16		48	60.0
Warfarin	A	0.75	0.92	0.1		1.1

A, acid; B, base; N, neutral.
↵ a Lab 1 = Lave et al. (1997a,b), Lab 2 = Schneider et al. (1999); Lab 3 = Lau et al. (2002); Lab 4 = Naritomi et al. (2003); Lab 5 = this laboratory; Lab 6 = Shibata et al. (2002).
↵ b Corrected for serum binding in assay.