TABLE 5

Human microsome data concordance across different laboratories for dataset studied

Compound	CL_int*, _{ub, in vitro}									CL_{int, ub, in vivo}
Compound		Lab 1	Lab 2	Lab 3	Lab 4	Lab 5	Lab 1	Lab 2	Lab 3	Lab 4	Lab 5
	ml/min/kg									ml/min/kg
Diazepam		8.3		20.13	6.8		33.8		20.1	30
Diclofenac	38.5	190.9	415.4		90.6	623.1	1348.4	2464.7		2233
Diltiazem		19.9		137	74.2		136.4		287.9	253
Ibuprofen	9.2 (2- and 3-OH)	10.6	20.6		8.9	91	89.2	81.2
										146
Tolbutamide	1.28	0.96	1.8		1.2	2.0	5.0	12.5
										6.1
Verapamil		286.6			951.5		2926.0			388.5
Zolpidem		4.9		31			75.7		155.3

Lab 1 = Carlile et al. (1999); Lab 2 = Obach (1999); Lab 3 = Andersson et al. (2004); Lab 4 = Naritomi et al. (2001); Lab 5 = this laboratory.