TABLE 1

Parameter estimates (CLup, kperfusate, k12, k21, and kbile) for CDF disposition in single-pass IPLs from control (90% propylene glycol/10% ethanol vehicle) and clofibric acid-treated rats using the model scheme shown in Fig. 1 (mean ± S.D., n = 3)

Parameter
Control
CA 100
CA 200
CLup (ml/min) 8.4 ± 1.2 7.0 ± 0.7 4.2 ± 0.4*
kperfusate (min–1) 0.014 ± 0.007 0.006 ± 0.005 0.019 ± 0.015
k12 (min–1) 0.061 ± 0.004 0.20 ± 0.14 0.22 ± 0.03
k21 (min–1) 0.031 ± 0.026 0.10 ± 0.04 0.084 ± 0.006
kbile (min–1)
0.21 ± 0.04
0.073 ± 0.009*
0.035 ± 0.006*

  • CA, clofibric acid.

  • ↵* P < 0.05 relative to control group