Drug | CLin | Linear Regression | r2 | CLin,u | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
2 mg/ml | 1 mg/ml | 0.5 mg/ml | 0.2 mg/ml | 0.1 mg/ml | ||||||||
μl/min/mg | μl/min/mg | |||||||||||
Desipramine | 5 ± 1 | 10 ± 1 | 14 ± 1 | 21 ± 2 | 29 ± 1 | y = 0.0931x + 0.0244 | 0.98 | 41 ± 12 | ||||
Amitryptiline | 17 ± 1 | 34 ± 3 | 48 ± 2 | 71 ± 5 | 76 ± 3 | y = 0.0238x + 0.0092 | 0.99 | 108 ± 16 | ||||
Imipramine | 14 ± 2 | 25 ± 3 | 32 ± 3 | 44 ± 3 | 59 ± 2 | y = 0.0271x + 0.0167 | 0.99 | 59 ± 6 | ||||
Verapamil | 73 ± 2 | 118 ± 9 | 153 ± 4 | 185 ± 3 | 187 ± 6 | y = 0.0045x + 0.0045 | 0.99 | 222 ± 15 | ||||
Diltiazem | 18 ± 2 | 31 ± 2 | 28 ± 2 | 33 ± 1 | 36 ± 2 | y = 0.0133x + 0.0262 | 0.88 | 38 ± 4 | ||||
Propafenone | 70 ± 4 | 87 ± 3 | 132 ± 4 | 168 ± 7 | 172 ± 1 | y = 0.0054x + 0.0047 | 0.96 | 185 ± 21 | ||||
Chlorpromazine | 27 ± 1 | 52 ± 1 | 84 ± 1 | 113 ± 3 | 128 ± 3 | y = 0.0154x + 0.0052 | 0.99 | 191 ± 33 | ||||
Midazolam | 196 ± 9 | 238 ± 6 | 287 ± 9 | 319 ± 22 | 318 ± 21 | y = 0.0011x + 0.0030 | 0.99 | 333 ± 11 | ||||
Diclofenac | 194 ± 10 | 225 ± 7 | 294 ± 8 | 349 ± 45 | 320 ± 21 | y = 0.0012x + 0.0029 | 0.94 | 344 ± 24 |
r, correlation coefficient of the linear fit.