Drug | CLin,u | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
LESA | Equilibrium Dialysis | Ultracentrifugation | Ultrafiltration | ||||||||||
1 mg/ml | 0.2 mg/ml | 1 mg/ml | 0.2 mg/ml | 1 mg/ml | 0.2 mg/ml | ||||||||
Desipramine | 41 ± 12 | 47 ± 4 | 32 ± 5 | 34 ± 1 | 34 ± 3 | 32 ± 2 | 35 ± 3 | ||||||
Amitryptiline | 108 ± 4 | 63 ± 18 | 86 ± 6 | 131 ± 8 | 99 ± 5 | 107 ± 7 | 119 ± 6 | ||||||
Imipramine | 59 ± 6 | 54 ± 12 | 53 ± 11 | 35 ± 2 | 39 ± 3 | 52 ± 3 | 58 ± 4 | ||||||
Verapamil | 222 ± 15 | 223 ± 18 | 256 ± 38 | 175 ± 16 | 170 ± 10 | 197 ± 10 | 210 ± 12 | ||||||
Diltiazem | 38 ± 4 | 28 ± 6 | 34 ± 2 | 34 ± 2 | 29 ± 1 | 32 ± 2 | 30 ± 1 | ||||||
Propafenone | 185 ± 21 | 114 ± 7 | 171 ± 18 | 116 ± 7 | 150 ± 10 | 127 ± 8 | 171 ± 11 | ||||||
Chlorpromazine | 191 ± 33 | 338 ± 27 | 353 ± 52 | 195 ± 9 | 167 ± 3 | N.D. | N.D. | ||||||
Midazolam | 333 ± 11 | 364 ± 26 | 325 ± 35 | 316 ± 19 | 285 ± 20 | 347 ± 24 | 325 ± 23 | ||||||
Diclofenac | 344 ± 24 | 252 ± 9 | 366 ± 28 | 363 ± 21 | 395 ± 34 | 372 ± 22 | 415 ± 35 |
N.D., not determined.