TABLE 4

Comparison of CL_in by the conventional method with that calculated by LESA

Values represent the mean ± S.E. of triplicate determinations.

Drug	CL_in,u
Drug		LESA Method^a	Conventional Method (Literature Data)^b
	μl/min/mg	μl/min/mg
2-Ethoxybenzamide	56 ± 6	45 ± 10
Albendazole	164 ± 33	200 ± 24
Amiodarone	N.D.^c	15721 ± 3521
Astemizole	450 ± 308	10327 ± 2112
Betaxolol	78 ± 5	84 ± 6
Bumetanide	143 ± 19	147 ± 11
Cerivastatin	34 ± 5	21 ± 7
Clozapine	588 ± 17	922 ± 89
Glyburide	230 ± 10	178 ± 34
Indapamide	32 ± 12	32 ± 7
Isradipine	N.D.^d	139 ± 10
Metyrapone	72 ± 9	38 ± 14
Oxaprozin	106 ± 2	96 ± 21

↵ a CL_in,u calculated by LESA method using published CL_in values obtained at 0.25, 1, and 4 mg/ml rat liver microsomes (Austin et al., 2002).
↵ b Average CL_in,u calculated from published CL_in and f_u values at 0.25, 1, and 4 mg/ml rat liver microsomes (Austin et al., 2002).
↵ c Not determined; intercept of the 1/CL_in vs. microsome concentration plot yielded a negative value.
↵ d LESA is not applicable since only two experimental CL_in values were reported.