In vitro and in vivo clearance of 7-ethoxycoumarin and warfarin
Study | In Vitro CLint | In Vivo CLh | Reference |
|---|---|---|---|
| μl/min/1 × 106 cells | ml/min/SRW | ||
| 7-Ethoxycoumarin | Well stirred/parallel tube | ||
| Sandwich culture | 45 | 6.7/7.9 | This study |
| Liver slices | 3.9 | 0.84/0.86 | Worboys et al. (1995) |
| Hepatocytes | 26.4 | 4.6/5.1 | Worboys et al. (1995) |
| Fresh hepatocytes | 3 | De Kanter et al. (2004) | |
| Liver slices | 4.7 | 1.0/1.0 | Axelsson et al. (2003) |
| Cryopreserved hepatocytes | 4.6 | 1.0/1.0 | Axelsson et al. (2003) |
| Hepatocytes | 98 | 10.5/13.3 | Carlile et al. (1998) |
| In vivo | 12/- | Carlile et al. (1998) | |
| Warfarin | |||
| Sandwich culture | 0.55 | 0.0095/0.0095 | This study |
| Liver slices | 0.01 | De Kanter et al. (2004) | |
| Fresh hepatocytes | 0.097 | 0.0017/0.0017 | Griffin and Houston (2004) |
| Cryopreserved hepatocytes | 0.229 | Griffin and Houston (2004) | |
| In vivo (S-warfarin) | 0.045 | Baars et al. (1990) | |
| In vivo (R-warfarin) |
| 0.135 | Baars et al. (1990) |