TABLE 2
Inhibition of gemcabene glucuronidation in human liver microsomes and recombinant UGTs with S-flurbiprofen and HMF
Values are mean ± standard deviation of three experiments. IC50 values for the inhibition of gemcabene glucuronidation by S-flurbiprofen and HMF were determined using substrate concentrations approximating the S50 values determined in HLM (1.37 mM) and each recombinant UGT isozyme (1A3, 0.92 mM; 2B7, 1.45 mM; and 2B17, 1.37 mM).