Tissue levels of ADR-925 in rats treated with either dexrazoxane, a B/C mixture, or ADR-925
The average tissue level of ADR-925 was measured per kilogram of wet tissue harvested from seven rats 2.8 h after dexrazoxane was administered (40 mg/kg), or the levels 1.5 h after the B/C mixture or ADR-925 was administrated (20 mg/kg) to three rats. ADR-925tot is the total amount of ADR-925 measured after treatment of the homogenate with NaOH to convert all forms of dexrazoxane into ADR-925. The limit of detection was 2 μmol/kg.
Treatment | |||||||
|---|---|---|---|---|---|---|---|
| Tissue | Dexrazoxane | B/C Mixture | ADR-925 | ||||
| ADR-925 | ADR-925tot | ADR-925 | ADR-925 | ||||
| μmol/kg | μmol/kg | μmol/kg | |||||
| Heart | 51 ± 6 | 100 ± 7 | 27 ± 6 | 7.4 ± 1.6 | |||
| Liver | 97 ± 14 | 232 ± 26 | 40 ± 16 | 10.6 ± 0.6 | |||
| Brain | <2 | <2 | <2 | <2 | |||