Up-regulation of referent drug-metabolizing enzymes by xenobiotics
Human hepatocytes were treated by prototypical xenobiotics for 72 h. mRNA levels were then determined by RT-qPCR.
Enzyme | Xenobiotic | -Fold Inductiona | Induction Range |
|---|---|---|---|
| CYP1B1 | TCDD | 445 ± 243.2 | 14.8-720.7 |
| CYP2B6 | PB | 23 ± 13.6 | 6.7-49.1 |
| CYP3A4 | RIF | 36.9 ± 35.5 | 7.5-110.1 |
| NQO1 | OPZ | 8.6 ± 5.4 | 2.5-15.3 |
↵ a Defined as the ratio of mRNA levels in treated hepatocytes versus those found in xenobiotic-untreated counterparts and expressed as mean ± S.D. of values from seven independent hepatocyte populations.