Gene | Accession Number | SD (Fold-induction) | SD+I (Fold-induction) | HF (Fold-induction) | HF+I (Fold-induction) | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Vehicle | PB | Vehicle | PB | Vehicle | PB | Vehicle | PB | ||||||
CYP2B1 | J00719 | 1.00 ± 0.19 | 331.21 ± 21.89+++ | 1.12 ± 0.58 | 318.29 ± 39.40+++ | 1.08 ± 0.42 | 288.76 ± 20.40+++ | 2.07 ± 1.41 | 225.16 ± 9.57**, +++, # | ||||
CYP2B2 | M34452 | 1.00 ± 0.17 | 75.03 ± 3.78+++ | 0.92 ± 0.17 | 71.39 ± 11.33+++ | 0.82 ± 0.10 | 44.80 ± 7.03***, +++ | 0.98 ± 0.22 | 39.71 ± 4.55***, +++ | ||||
CYP2C11 | NM_019184 | 1.00 ± 0.12 | 1.49 ± 0.43 | 0.79 ± 0.14 | 2.80 ± 0.05 | 2.21 ± 0.62 | 2.92 ± 1.38 | 6.50 ± 4.86 | 3.46 ± 1.89 | ||||
CYP2E1 | NM_031543 | 1.00 ± 0.19 | 0.76 ± 0.05 | 0.96 ± 0.03 | 0.66 ± 0.08+ | 0.69 ± 0.02* | 0.37 ± 0.02**, + | 0.57 ± 0.03** | 0.32 ± 0.07**, + | ||||
CYP3A1 | NM_173144 | 1.00 ± 0.05 | 15.47 ± 0.92+++ | 0.92 ± 0.09 | 10.55 ± 1.78+++ | 1.14 ± 0.17 | 7.67 ± 1.26***, +++ | 1.01 ± 0.30 | 5.34 ± 0.46***, +++, # | ||||
CYP3A2 | NM_153312 | 1.00 ± 0.38 | 9.99 ± 3.22+++ | 0.43 ± 0.05 | 6.73 ± 1.73+ | 0.99 ± 0.22 | 5.45 ± 2.22 | 1.24 ± 0.08 | 4.26 ± 0.36 | ||||
CYP4A1 | M57718 | 1.00 ± 0.09 | 0.88 ± 0.09 | 1.24 ± 0.23 | 0.75 ± 0.04+ | 0.71 ± 0.09 | 0.52 ± 0.09* | 0.54 ± 0.06 | 0.75 ± 0.18 | ||||
CYP4A2 | M57719 | 1.00 ± 0.04 | 1.96 ± 0.48+ | 1.75 ± 0.67 | 1.07 ± 0.47 | 0.58 ± 0.09 | 0.53 ± 0.09** | 0.38 ± 0.03 | 0.37 ± 0.03** | ||||
CYP4A3 | M33936 | 1.00 ± 0.14 | 1.58 ± 0.23 | 1.09 ± 0.16 | 1.11 ± 0.20 | 0.96 ± 0.12 | 1.09 ± 0.12 | 0.92 ± 0.01 | 0.63 ± 0.01**, # | ||||
NADPH-cytochrome P450 reductase | NM_031576 | 1.00 + 0.09 | 11.82 + 0.12+ | 1.00 + 0.07 | 2.44 + 0.41+++ | 0.95 + 0.22 | 1.57 + 0.22 | 0.84 + 0.20 | 1.07 + 0.25* | ||||
CAR | NM_022941 | 1.00 ± 0.10 | 0.51 ± 0.09 | 0.71 ± 0.20 | 0.36 ± 0.07 | 1.80 ± 0.21 | 0.76 ± 0.24 | 2.32 ± 0.89* | 0.57 ± 0.17 | ||||
PXR | NM_052980 | 1.00 ± 0.09 | 0.54 ± 0.09 | 0.83 ± 0.07 | 0.45 ± 0.03 | 0.84 ± 0.15 | 0.64 ± 0.21 | 0.81 ± 0.29 | 0.36 ± 0.08 | ||||
RXRα | NM_012805 | 1.00 ± 0.08 | 1.30 ± 0.11 | 1.48 ± 0.10 | 1.38 ± 0.10 | 1.23 ± 0.20 | 1.19 ± 0.10 | 1.01 ± 0.06 | 0.83 ± 0.14 | ||||
HNF4α | NM_022180 | 1.00 ± 0.06 | 1.04 ± 0.13 | 0.97 ± 0.03 | 1.04 ± 0.07 | 0.86 ± 0.05 | 0.77 ± 0.07 | 0.76 ± 0.13 | 0.48 ± 0.05**, # | ||||
PGC-1α | AY237127 | 1.00 ± 0.40 | 0.43 ± 0.07 | 0.94 ± 0.48 | 0.69 ± 0.25 | 0.70 ± 0.30 | 0.69 ± 0.16 | 0.88 ± 0.18 | 0.46 ± 0.17 |
↵* p < 0.05, ** p < 0.01, *** p < 0.001 for SD + I-, HF-, or HF + I-fed and vehicle-administered animals versus SD-fed and vehicle-administered animals or SD + I-, HF-, or HF + I-fed and PB-administered animals versus SD-fed and PB-administered animals.
↵+ p < 0.05, +++p < 0.001 for PB-administered animals versus vehicle-administered animals.
↵# p < 0.05 for HF + I-fed and vehicle-administered animals versus HF-fed and vehicle-treated animals or HF + I-fed and PB-treated animals versus HF-fed and PB-treated animals.