TABLE 2

Liver gene expression in rats fed SD-, SD + I-, HF-, or HF + I for 8 weeks and administered PB (80 mg/kg, i.p.) once daily for 4 days

Values are means ± S.E. of three to five determinations.

Gene	Accession Number	SD (Fold-induction)			SD+I (Fold-induction)			HF (Fold-induction)			HF+I (Fold-induction)
Gene	Accession Number			Vehicle	PB	Vehicle	PB	Vehicle	PB	Vehicle	PB
CYP2B1	J00719	1.00 ± 0.19	331.21 ± 21.89⁺⁺⁺	1.12 ± 0.58	318.29 ± 39.40⁺⁺⁺	1.08 ± 0.42	288.76 ± 20.40⁺⁺⁺	2.07 ± 1.41	225.16 ± 9.57**^, ⁺⁺⁺^, ^#
CYP2B2	M34452	1.00 ± 0.17	75.03 ± 3.78⁺⁺⁺	0.92 ± 0.17	71.39 ± 11.33⁺⁺⁺	0.82 ± 0.10	44.80 ± 7.03***^, ⁺⁺⁺	0.98 ± 0.22	39.71 ± 4.55***^, ⁺⁺⁺
CYP2C11	NM_019184	1.00 ± 0.12	1.49 ± 0.43	0.79 ± 0.14	2.80 ± 0.05	2.21 ± 0.62	2.92 ± 1.38	6.50 ± 4.86	3.46 ± 1.89
CYP2E1	NM_031543	1.00 ± 0.19	0.76 ± 0.05	0.96 ± 0.03	0.66 ± 0.08⁺	0.69 ± 0.02*	0.37 ± 0.02**^, ⁺	0.57 ± 0.03**	0.32 ± 0.07**^, ⁺
CYP3A1	NM_173144	1.00 ± 0.05	15.47 ± 0.92⁺⁺⁺	0.92 ± 0.09	10.55 ± 1.78⁺⁺⁺	1.14 ± 0.17	7.67 ± 1.26***^, ⁺⁺⁺	1.01 ± 0.30	5.34 ± 0.46***^, ⁺⁺⁺^, ^#
CYP3A2	NM_153312	1.00 ± 0.38	9.99 ± 3.22⁺⁺⁺	0.43 ± 0.05	6.73 ± 1.73⁺	0.99 ± 0.22	5.45 ± 2.22	1.24 ± 0.08	4.26 ± 0.36
CYP4A1	M57718	1.00 ± 0.09	0.88 ± 0.09	1.24 ± 0.23	0.75 ± 0.04⁺	0.71 ± 0.09	0.52 ± 0.09*	0.54 ± 0.06	0.75 ± 0.18
CYP4A2	M57719	1.00 ± 0.04	1.96 ± 0.48⁺	1.75 ± 0.67	1.07 ± 0.47	0.58 ± 0.09	0.53 ± 0.09**	0.38 ± 0.03	0.37 ± 0.03**
CYP4A3	M33936	1.00 ± 0.14	1.58 ± 0.23	1.09 ± 0.16	1.11 ± 0.20	0.96 ± 0.12	1.09 ± 0.12	0.92 ± 0.01	0.63 ± 0.01**^, ^#
NADPH-cytochrome P450 reductase	NM_031576	1.00 + 0.09	11.82 + 0.12⁺	1.00 + 0.07	2.44 + 0.41⁺⁺⁺	0.95 + 0.22	1.57 + 0.22	0.84 + 0.20	1.07 + 0.25*
CAR	NM_022941	1.00 ± 0.10	0.51 ± 0.09	0.71 ± 0.20	0.36 ± 0.07	1.80 ± 0.21	0.76 ± 0.24	2.32 ± 0.89*	0.57 ± 0.17
PXR	NM_052980	1.00 ± 0.09	0.54 ± 0.09	0.83 ± 0.07	0.45 ± 0.03	0.84 ± 0.15	0.64 ± 0.21	0.81 ± 0.29	0.36 ± 0.08
RXRα	NM_012805	1.00 ± 0.08	1.30 ± 0.11	1.48 ± 0.10	1.38 ± 0.10	1.23 ± 0.20	1.19 ± 0.10	1.01 ± 0.06	0.83 ± 0.14
HNF4α	NM_022180	1.00 ± 0.06	1.04 ± 0.13	0.97 ± 0.03	1.04 ± 0.07	0.86 ± 0.05	0.77 ± 0.07	0.76 ± 0.13	0.48 ± 0.05**^, ^#
PGC-1α	AY237127	1.00 ± 0.40	0.43 ± 0.07	0.94 ± 0.48	0.69 ± 0.25	0.70 ± 0.30	0.69 ± 0.16	0.88 ± 0.18	0.46 ± 0.17

↵* p < 0.05, ** p < 0.01, *** p < 0.001 for SD + I-, HF-, or HF + I-fed and vehicle-administered animals versus SD-fed and vehicle-administered animals or SD + I-, HF-, or HF + I-fed and PB-administered animals versus SD-fed and PB-administered animals.
↵+ p < 0.05, ⁺⁺⁺p < 0.001 for PB-administered animals versus vehicle-administered animals.
↵# p < 0.05 for HF + I-fed and vehicle-administered animals versus HF-fed and vehicle-treated animals or HF + I-fed and PB-treated animals versus HF-fed and PB-treated animals.