Elimination Rate | |||
---|---|---|---|
+NADPH | -NADPH | ||
pmol/min/mg MSP | |||
Deltamethrin | |||
Rat microsomes | 30.4 ± 7.3 | 8.8 ± 0.23 | |
Rat microsomes + TEPPa | 24.6 ± 3.7 | N.D. | |
Human microsomes | 52.8 ± 6.2 | 58.0 ± 3.0 | |
Human microsomes + TEPPa | 5.8 ± 5.4 | N.D. | |
Esfenvalerate | |||
Rat microsomes | 45.3 ± 2.4 | 4.8 ± 1.4 | |
Rat microsomes + TEPPa | 23.4 ± 9.0 | N.D. | |
Human microsomes | 20.9 ± 4.4 | 2.6 ± 1.6 | |
Human microsomes + TEPPa | 18.9 ± 2.7 | N.D. |
+NADPH, total clearance (oxidative and hydrolytic) of parent chemical from microsomal assay; -NADPH, NADPH-independent hydrolytic clearance of parent chemical from microsomal incubation; N.D., no detectable elimination.
↵ a TEPP (200 μM) was used to inhibit hydrolytic metabolism.