TABLE 1

Kinetic parameters of endosulfan-α metabolism in pHLMs, recombinant CYP2B6, and 3A4

HLM or P450
Km
Vmax
CLint
μM
pHLM 9.8 178.5a 18.20b
CYP2B6 16.2 11.4c 0.70d
CYP3A4
14.4
1.3
0.09

  • ↵ a Vmax expressed in pmol/min/mg protein for pHLM.

  • ↵ c Vmax expressed in pmol/min/pmol P450 for CYP2B6 and 3A4.

  • ↵ b Intrinsic clearance (Vmax/Km) expressed in μl/min/mg protein for pHLMs.

  • ↵ d Intrinsic clearance (Vmax/Km) expressed in μl/min/pmol P450 for CYP2B6 and 3A4.