HLMs | rP450 | Endosulfan Sulfate Formation Ratea in rP450 | P450 Contentb in Native HLMs | Normalized Rate | % TNR | % I |
---|---|---|---|---|---|---|
HG42 | 2B6 | 9.42 | 53 | 499.37 | 64.8 | 79.3 |
2C9 | 0.34 | 80 | 24.12 | 3.5 | N.D. | |
2C19 | 0.32 | 6 | 1.89 | 0.2 | N.D. | |
3A4 | 0.78 | 310 | 242.73 | 31.5 | 8.6 | |
HG112 | 2B6 | 9.42 | 47 | 442.83 | 58.8 | 64.4 |
2C9 | 0.34 | 87 | 29.49 | 3.9 | N.D. | |
2C19 | 0.32 | 72 | 22.68 | 3.0 | N.D. | |
3A4 | 0.78 | 330 | 258.39 | 34.3 | 20.5 | |
HG3 | 2B6 | 9.42 | 18 | 169.60 | 65.0 | 67.9 |
2C9 | 0.34 | 42 | 14.24 | 5.0.4 | N.D. | |
2C19 | 0.32 | 9 | 2.84 | 1.1 | N.D. | |
3A4 | 0.78 | 95 | 74.38 | 28.5 | 23.8 | |
HK23 | 2B6 | 9.42 | 7 | 65.95 | 42.1 | 33.0 |
2C9 | 0.34 | 56 | 18.98 | 12.1 | N.D. | |
2C19 | 0.32 | 17 | 5.36 | 3.4 | N.D. | |
3A4 | 0.78 | 85 | 66.56 | 42.4 | 36.0 | |
HG43 | 2B6 | 9.42 | 4 | 37.69 | 26.3 | 57.0 |
2C9 | 0.34 | 51 | 17.29 | 12.1 | N.D. | |
2C19 | 0.32 | 47 | 14.81 | 10.3 | N.D. | |
3A4 | 0.78 | 94 | 73.60 | 51.3 | 34.9 | |
HG93 | 2B6 | 9.42 | 18 | 169.60 | 69.0 | 38.6 |
2C9 | 0.34 | 51 | 17.29 | 7.3 | N.D. | |
2C19 | 0.32 | 49 | 15.44 | 6.7 | N.D. | |
| 3A4 | 0.78 | 52 | 40.72 | 17.0 | 37.6 |