Dual inhibition of capravirine (CPV) metabolism in human liver microsomal incubations
Inhibitor (P450) | Metabolite Formation | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| CPV | C19 | C20 | C23 | C26 | |||||
| % | |||||||||
| Ritonavir (3A4) | 97.51 | 0.18 | 0.58 | 0.41 | 1.33 | ||||
| Ritonavir (3A4) + Quercetin (2C8) | 99.24 | 0.05 | 0.19 | 0.21 | 0.31 | ||||
| Ritonavir (3A4) + Sulfaphenazole (2C9) | 97.18 | 0.15 | 0.34 | 0.61 | 1.72 | ||||
| Ritonavir (3A4) + Ticlopidine (2C19) | 96.78 | 0.08 | 0.73 | 0.44 | 1.97 | ||||