Pharmacokinetic parameters of irofulven and radioactivity in humans (mean ± S.D.)
Parameter | Total Radioactivity | Irofulven |
|---|---|---|
| Cmax (ng/ml) | 1130 ± 174 | 82.7 ± 46.0 |
| 1120 a | 71.4 a | |
| Tmax (h) | 0.72 ± 0.12 | 0.29 ± 0.10 |
| AUC(0-t) (ng · h/ml) | 15,000 ± 634 | 30.6 ± 25.8 |
| 15,000 a | 17.7 a | |
| AUC(0-∞) (ng · h/ml) | 24,400 ± 1780 | 65.5 ± 2.4 |
| 24,300 a | 65.4 a | |
| t1/2 (h) terminal half-life | 116.5 ± 27.1 | 0.3 ± 0.1 |
| CLP (l/h/kg) | 8.48 ± 0.14 | |
| Vdss (l/kg) | 3.12 ± 1.99 | |
| AUC(0-t) ratiob | 0.00209 ± 0.00180 | |
| 14C-AUC(0-t) blood/plasma ratio | 1.58 ± 0.737 | |
| 14C-Cmax blood/plasma ratio | 0.820 ± 0.205 |
|