Kinetic parameters of metabolism for genistein, daidzein, formononetin, glycitein, biochanin A, and prunetin by rat colon microsomes
Isoflavone | Genistein | Daidzein | Formononetin | Glycitein | Biochanin A | Prunetin | |
|---|---|---|---|---|---|---|---|
| Colon | Vmax1 (nmol/min/mg) | 0.4 | 0.8 | 0.5 | 2.5 | 0.3 | 0.1 |
| Km1 (μM) | 3.2 | 4.3 | 8.4 | 0.6 | 13.0 | 0.7 | |
| Vmax1/Km1 (ml/min/mg) | 0.1 | 0.2 | 0.1 | 3.8 | 0.02 | 0.2 | |
| R (autoact only) | 0.5 | ||||||
| Vmax-0 (autoact) (nmol/min/mg) | 0.01 | ||||||
| Vmax-d (autoact) (nmol/min/mg) | 2.5 | ||||||
| Vmax2 (biphasic) (nmol/min/mg) | 1.6E3 | 0.1 | |||||
| Km2 (μM) | 2.7E5 | 0.1 | |||||
| R 2 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | |
|
| AIC | -53.6 | -34.2 | -38.6 | -8.4 | -51.6 | -73.2 |