Mean (S.D.) pharmacokinetic parameters of nebicapone and its metabolites BIA 3-476 and BIA 3-270 in humans after p.o. administration of nebicapone (n = 6)
Tmax values are the median with range values in parentheses.
Cmax | Tmax | AUC0-24 | |
|---|---|---|---|
| μM | h | h/μM | |
| Nebicapone | 28.3 (1.4) | 1.3(0.5-3) | 99.1 (17.2) |
| BIA 3-476 | 60.8 (7.8) | 2.5(1.5-4) | 303.1 (96.3) |
| BIA 3-270 | 1.7 (0.1) | 12 (8-18) | 30.6 (9.1) |