TABLE 1

Material balance and routes of excretion of [14C]varenicline drug-related material in mice, rats, monkeys, and humans

Values represent mean ± S.D.


Species

Percentage of Dose in Urine

Percentage of Dose in Feces

Percentage of Dose Recovereda
Mouse 83.1 ± 8.2 10.8 ± 5.1 94.4 ± 6.7
Rat 68.1 ± 10.2 22.3 ± 6.3 90.4 ± 6.4
Monkey 74.1 ± 2.3 6.5 ± 0.5 87.5 ± 5.0
Human
87.1 ± 5.5
0.9 ± 0.5
88.0 ± 5.7
  • a Percentage of dose recovered also includes cage washes.