Pharmacokinetic parameters of itraconazole and hydroxyitraconazole following a single administration of 50 mg, 100 mg, and 200 mg of itraconazole
Data represent mean ± S.D.; tmax data are given as median with range.
Parameters | Dose | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 50 mg | 100 mg | p Value | 200 mg | p Values | |||||
| Itraconazole | |||||||||
| tmax (h) (range) | 4 (3-8) | 4 (3-6) | 1.000 | 3 (2-4) | 0.175 | ||||
| Cmax (ng/ml) | 18 ± 7 | 56 ± 25 | 0.003 | 98 ± 24 | <0.001 | ||||
| AUC0-48 (ng h ml-1) | 214 ± 113 | 397 ± 126 | 0.027 | 772 ± 362 | 0.003 | ||||
| CL/F(ml h-1 kg-1) | 5463 ± 3077 | 4798 ± 1366 | 1.000 | 5391 ± 2049 | 1.000 | ||||
| Hydroxyitraconazole | |||||||||
| tmax (h) (range) | 5 (3-6) | 4 (3-6) | 0.576 | 4 (3-8) | 0.848 | ||||
| Cmax (ng ml-1) | 48 ± 18 | 120 ± 34 | <0.001 | 193 ± 60 | 0.001 | ||||
| AUC0-48 (ng h ml-1) | 549 ± 229 | 1065 ± 522 | 0.021 | 2048 ± 1118 | 0.003 | ||||
ap values, compared with the 50-mg itraconazole treatment.