Metabolite | % of Dose | ||
---|---|---|---|
Monkeys | Humans | ||
FYX-051 | 0.4 ± 0.1 | <0.1 | |
N-Oxide | 0.1 ± 0.1 | 4.8 ± 0.8 | |
Hydroxide | <0.1 | 0.1 ± 0.1 | |
N1-Glucuronide | 39.7 ± 12.2 | 43.3 ± 2.9 | |
N2-Glucuronide | 8.2 ± 1.2 | 16.1 ± 1.1 | |
N1-Glucoside | N.D. | N.D. | |
N2-Glucoside | N.D. | N.D. | |
Total | 48.4 ± 12.5 | 64.3 ± 4.4 |
N.D., not determined (less than 0.01% of the dose).