Parent Chemical | Metabolite | Vmax | Km | CLint (Vmax/Km) | R2 |
---|---|---|---|---|---|
pmol/mg protein/min | μM | μl/mg protein/min | |||
pHLM | |||||
1-Naphthol | 1,4-NapQ | N.D. | N.D. | N.D. | |
2-Naphthol | 2,6-DiOH | 322.6 ± 25.0 | 7.0 ± 1.1 | 47459 | 0.98 |
1,7-DiOH | 132.1 ± 6.5 | 12.3 ± 1.2 | 10978 | 0.99 | |
pmol/pmol 1A2/min | μM | μl/nmol 1A2/min | |||
CYP1A2 | |||||
1-Naphthol | 1,4-NapQ | 10.8 ± 0.4 | 28.7 ± 1.4 | 378 | 0.99 |
2-Naphthol | 2,6-DiOH | 45.2 ± 1.3 | 25.2 ± 2.0 | 1805 | 0.98 |
| 1,7-DiOH | 6.4 ± 0.3 | 43.2 ± 4.1 | 149 | 0.97 |
1,4-NapQ, 1,4-naphthoquinone; 2,6-DiOH, 2,6-dihydroxynaphthalene; 1,7-DiOH, 1,7-dihydroxynaphthalene; N.D., not determined.