IC50a | ||||||||
---|---|---|---|---|---|---|---|---|
Enzyme | P450 Reaction | Gemfibrozil | Gemfibrozil Glucuronide | |||||
No Preincubation | 30-min Preincubation | No Preincubation | 30-min Preincubation | |||||
μM | μM | |||||||
CYP1A2 | Phenacetin O-deethylation | 99 ± 12 | 84 ± 6 | 250 ± 40 | >300 | |||
CYP2B6 | Bupropion hydroxylation | >300 | >300 | >300 | >300 | |||
CYP2C8 | Paclitaxel 6α-hydroxylation | 120 ± 20 | 150 ± 20 | 24 ± 5 | 1.8 ± 0.5 | |||
CYP2C9 | Diclofenac 4′-hydroxylation | 30 ± 2 | 30 ± 3 | >300 | >300 | |||
CYP2C19 | S-Mephenytoin 4′-hydroxylation | 100 ± 10 | 82 ± 18 | >300 | >300 | |||
CYP2D6 | Dextromethorphan O-demethylation | >300 | >300 | >300 | >300 | |||
CYP3A4/5 | Testosterone 6β-hydroxylation | >300 | >300 | >300 | >300 | |||
CYP3A4/5 | Midazolam 1′-hydroxylation | >300 | >300 | >300 | >300 |
↵ a Values are displayed to two significant figures, ± standard error.