TABLE 1

H NMR results for piperaquine and its metabolites

Molecule	Proton	Multiplicity	δ	J
			ppm	Hz
Piperaquine
(aromatic region)	H-14/H-34	D	8.48	6.8
	H-10/H-30	D	7.99	9.1
	H-9/H-29	D	7.94	1.9
	H-7/H-27	Q	7.61	9.2/1.9
	H-15/H-35	D	7.14	6.8
(aliphatic region)	H-1-H-3/H-21-H-23	S	3.96
	H-4-H-6/H-24-H-26	S	3.55
	H-18/H-20	T	3.24	8.3
	H-19	M	2.26
Metabolite 1
(aromatic region)	H-14	D	8.47	6.7
	H-10	D	7.98	9.1
	H-9	S	7.93
	H-7	D	7.61	9.0
	H-15	D	7.13	6.7
(aliphatic region)	H-1-H-3	S	4.22
	H-4-H-6	S	3.70
	H-18	T	3.48	6.8
	H-19	T	2.85	6.7
Metabolite 2
(aromatic region)	H-34	D	8.58	6.9
	H-14	D	8.49	6.8
	H-29	S	8.38
	H-30	D	8.04	9.2
	H-10	D	8.00	9.2
	H-9	S	7.94
	H-27	D	7.67	9.2
	H-7	D	7.62	9.2
	H-15	D	7.15	6.9
	H-35	D	7.08	7.0
(aliphatic region)	H-1-H-3/H-21-H-23	S	3.70
	H-4-H-6/H-24-H-26	S	3.50
	H-18/H-20	T	3.30	7.9
	H-19	M	2.28
Metabolites 3 and 4
(aromatic region)	H-14/H-34	D	8.48	6.5
	H-10/H-30	D	7.98	9.2
	H-9/H-29	S	7.94
	H-7/H-27	D	7.61	8.6
	H-15/H-35	D	7.14	7.0
(aliphatic region)	Multiple peaks
Metabolite 5	Weak signal with multiple peaks