Tissue | 250 mg | 1000 mg | 1000 mg with ABT | ||||||
---|---|---|---|---|---|---|---|---|---|
WT | KO | WT | KO | WT | KO | ||||
Blood | 42.6 ± 2.0 | 61.5 ± 6.5a | 342.8 ± 35.2 | 285.6 ± 12.5 | 88.7 ± 4.5 | 85.7 ± 2.3 | |||
Kidneys | 64.9 ± 1.2 | 72.3 ± 2.1a | 333.6 ± 22.6 | 269.4 ± 17.3a | 222.9 ± 6.1 | 190.1 ± 13.5a | |||
Thymus | 24.9 ± 0.2 | 25.29 ± 0.8 | 135.9 ± 24.6 | 107.9 ± 16.5 | 52.1 ± 4.2 | 44.1 ± 2.5 | |||
Heart | 14.9 ± 0.8 | 17.4 ± 1.0 | 131.6 ± 10.9 | 103.2 ± 12.3 | 29.1 ± 0.7 | 23.3 ± 1.3a | |||
Forestomach | 204.8 ± 54.3 | 254.3 ± 75.1 | 942.4 ± 105.4 | 567.2 ± 23.5a | 351.4 ± 34.3 | 359.5 ± 25.4 | |||
Glandular stomach | 44.74 ± 3.8 | 47.9 ± 5.6 | 395.9 ± 57.2 | 296.6 ± 36.6 | 136.7 ± 21.6 | 126.2 ± 12.2 | |||
Fat | 3.8 ± 0.5 | 3.4 ± 0.3 | 32.1 ± 6.0 | 20.2 ± 0.6 | 16.2 ± 0.3 | 16.9 ± 0.9 | |||
Liver | 123.6 ± 5.7 | 123.1 ± 6.8 | 928.2 ± 82.3 | 803.5 ± 43.4 | 203.8 ± 3.1 | 194.8 ± 4.9 | |||
Spleen | 20.9 ± 0.8 | 29.1 ± 1.8a | 228.6 ± 25.0 | 213.5 ± 9.7 | 50.4 ± 2.3 | 45.7 ± 2.0 | |||
Lung | 21.6 ± 1.8 | 30.0 ± 1.7a | 202.4 ± 14.1 | 181.3 ± 9.4 | 42.1 ± 1.7 | 36.2 ± 1.4a | |||
Testes | 8.1 ± 0.5 | 12.1 ± 0.5a | 85.7 ± 10.2 | 60.3 ± 1.2a | 17.6 ± 1.0 | 16.4 ± 1.3 | |||
Brain | 4.1 ± 0.4 | 6.0 ± 0.5a | 43.8 ± 4.9 | 27.6 ± 2.1a | 8.9 ± 0.5 | 7.7 ± 0.4a |
↵ a Values in KO mice that are significantly different from values in similarly treated WT mice at p ≤ 0.05. Tissue concentrations of TCE-derived radioactivity in mice treated with 1000 mg TCE/kg are significantly different in mice of the same genotype that received 250 mg TCE/kg at p ≤ 0.05. Tissue concentrations of TCE-derived radioactivity in mice treated with ABT + 1000 mg TCE/kg are significantly different from values in mice that received 1000 mg TCE/kg without ABT at p ≤ 0.05.