Ki values (μM) obtained with five probe substrates, i.e, (S)-flurbiprofen, (S)-warfarin, phenytoin, tolbutamide, and diclofenac, using CYP2C9.3
Global standard error for data fitting was less than 15% and r2 > 0.9 for each effector.
Inhibitors | Flurbiprofen | Warfarin | Phenytoin | Tolbutamide | Diclofenac |
|---|---|---|---|---|---|
| Mibefradil | 13.08 | 1.80 | 6.90 | 6.90 | 14.30 |
| Indomethacin | 38.74 | 5.04 | 12.66 | 16.87 | 25.62 |
| Benzbromarone | 1.54 | 0.01 | 0.71 | 0.03 | 0.04 |
| Sulfaphenazole | 0.72 | 0.15 | 0.39 | 0.33 | 0.36 |
| Nicardipine | 0.29 | 0.01 | 0.02 | 0.02 | 0.02 |
| (S)-Ibuprofen | 9.78 | 3.15 | 5.50 | 14.03 | 14.68 |
| Amiodarone | 3.64 | 1.66 | 1.87 | 0.81 | 2.10 |
| Sulfamethizole | 35.04 | 3.87 | 24.74 | 25.93 | 31.86 |
| Omeprazole | 16.24 | 0.90 | 1.60 | 1.46 | 0.30 |
| Clozapine | 10.49 | 2.80 | 5.07 | 5.92 | 8.04 |
| Gemfibrozil | 14.33 | 1.65 | 4.95 | 7.21 | 14.41 |
| Ketoconazole | 1.51 | 0.08 | 0.69 | 0.70 | 0.79 |
| Progesterone | 11.03 | 1.97 | 3.27 | 2.58 | 7.91 |
| Nifedipine | 1.53 | 0.28 | 0.61 | 0.28 | 1.18 |
| Thiobendazole | >100 | 11.02 | 26.92 | 24.54 | 69.85 |
| Quinine | 21.2 | 18.89 | 39.68 | 86.52 | 96.70 |
| Quercetin | 0.25 | 0.11 | 0.29 | 0.08 | 0.13 |
| Fluvoxamine | 4.19 | 0.67 | 2.37 | 1.57 | 2.53 |
| Tamoxifen | 9.77 | 0.58 | 6.69 | 2.72 | 8.36 |
| Miconazole | 0.10 | 0.02 | 0.12 | 0.06 | 0.07 |
| α-Naphthoflavone | 1.13 | 0.18 | 0.39 | 0.24 | 0.44 |
| Diclofenac | 5.34 | 1.16 | 3.32 | 2.58 | |
| Flurbiprofen | 5.27 | 23.15 | 33.49 | 23.66 | |
| Warfarin | 2.70 | 11.12 | 5.89 | 12.21 | |
| Phenytoin | 24.20 | 5.93 | 6.99 | 16.53 | |
| Tolbutamide | 12.91 | 2.30 | 5.51 | 9.54 | |
| Piroxicam | 19.38 | 1.27 | 8.67 | 7.40 | 6.05 |
| Vivid Green | 1.59 | 0.44 | 0.70 | 2.53 | 0.84 |
| Dapsone | >100 | 0.26 | 10.47 | 12.76 | 15.62 |