TABLE 7

Predicted and empirical physicochemical properties of molecules tested in vitro

Name
Molecular Weight
cLogPa
Solubility
Bioavailability
%
Acitretin 326.4 4.84 223.32 nM 59
Cholecalciferol 384.6 6.83 Insoluble 60
Miconazole 416.1 6.02 28.88 mM 25-30
Misoprostol 382.5 3.37 4.2 mM >80
Nafcillin 414.5 3.37 Soluble 50
Repaglinide 452.6 5.80 Insoluble 56 ± 7
Salmeterol 415.6 5.02 Slightly soluble Undetected
Telmisartan 514.6 7.25 Insoluble 43-50
Phenelzine 136.2 0.77 124.2 mM N.A.
Zonisamide
212.2
0.87
3.42 mM
N.A.