Pathways triggered by coumarin in vivo, in the standard model, or in the modified model
Pathway | In Vivo | Standard Model | Modified Model | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Significant/Signal | p Value | Significant/Signal | p Value | Significant/ Signal | p Value | ||||
| Fatty acid metabolism | 12/34 | 0.024* | 0/35 | 1.000 | 4/36 | 0.049* | |||
| Tryptophan metabolism | 11/28 | 0.013* | 0/26 | 1.000 | 3/27 | 0.085 | |||
| Complement and coagulation cascades | 10/28 | 0.036* | 0/29 | 1.000 | 4/27 | 0.019* | |||
| Citrate cycle (TCA cycle) | 6/11 | 0.011* | 0/11 | 1.000 | 2/11 | 0.065 | |||
| γ -Hexachlorocyclohexane degradation | 8/15 | 0.004* | 0/14 | 1.000 | 3/14 | 0.015* | |||
| Urea cycle and metabolism of amino groups | 2/8 | 0.492 | 0/9 | 1.000 | 2/9 | 0.045* | |||
| Nitrogen metabolism | 3/8 | 0.199 | 0/7 | 1.000 | 2/7 | 0.028* | |||
| Seleno-amino acid metabolism | 2/3 | 0.102 | 0/7 | 1.000 | 2/7 | 0.028* | |||
| Cysteine metabolism | 3/6 | 0.096 | 0/6 | 1.000 | 2/5 | 0.014* | |||
| Methionine metabolism | 3/4 | 0.026* | 0/6 | 1.000 | 3/6 | 0.001* | |||
| Glutathione metabolism | 4/13 | 0.246 | 2/16 | 0.003* | 1/15 | 0.449 | |||
↵* p < 0.05 calculated by Fisher's exact test; the significant/signal column represents the number of genes in the pathway significantly altered by coumarin versus the number of genes in that pathway present in the complete data set.