[14C]Naphthalene | [3H]Raloxifene | ||
---|---|---|---|
pmol/mg protein | |||
Control t = 120 s | 1950 ± 144 | 589 ± 13 | |
t = 0 | 189 ± 74* | 3 ± 1* | |
No NADPH | 250 ± 6* | 34 ± 5* | |
With 10 mM GSH | 35 ± 4* | 92 ± 11* | |
Ketoconazole | |||
10 μM | 1820 ± 62 | 345 ± 7* | |
5 μM | 1740 ± 301 | 423 ± 36* | |
1 μM | 1960 ± 188 | 493 ± 33* | |
0.5 μM | 2150 ± 114 | 538 ± 63 | |
0.1 μM | 2080 ± 23 | 667 ± 59 | |
0.05 μM | 2070 ± 107 | 609 ± 98 | |
Verapamil | |||
500 μM | 2020 ± 123 | 545 ± 27 | |
250 μM | 2070 ± 155 | 652 ± 36 | |
100 μM | 2200 ± 104 | 485 ± 138 | |
50 μM | 2210 ± 38 | 619 ± 52 | |
10 μM | 2000 ± 490 | 636 ± 139 | |
1 μM | 1960 ± 177 | 658 ± 34 | |
4-Methylpyrazole | |||
5000 μM | 27 ± 1* | N.A. | |
1000 μM | 104 ± 12* | N.A. | |
500 μM | 190 ± 4* | N.A. | |
250 μM | 311 ± 26* | N.A. | |
100 μM | 447 ± 16* | N.A. | |
10 μM | 622 ± 22* | N.A. |
N.A., data not available.
↵* p < 0.01.