The prediction of human clearance by the PBPK model and the published interspecies extrapolation methods of Caldwell et al. ( 2004 ) and Ward and Smith ( 2004 ) for the respective training sets
The value of n corresponds to the number of compounds in each training set.
Caldwell et al. (n = 176) | Ward and Smith (n = 97) | PBPK Model (n = 69) | |||
|---|---|---|---|---|---|
| Method I | Method II | ||||
| Average Fold Error | 2.16 | 2.22 | 2.64 | 2.51 | |
| -Fold Error <2 (%) | 56 | 52 | 49 | 46 | |
| -Fold Error <3 (%) | 77 | 79 | 70 | 72 | |
| -Fold Error <4 (%) | 88 | 86 | 79 | 75 | |