The prediction of human clearance by the PBPK model and the published interspecies scaling methods of Caldwell et al. (2004) and Ward and Smith(2004) for the PBPK model test set (n = 18)
Caldwell et al. | Ward and Smith | PBPK Model | |||
|---|---|---|---|---|---|
| Method I | Method II | ||||
| Average Fold Error | 2.61 | 2.53 | 3.44 | 2.78 | |
| -Fold Error <2 (%) | 50 | 50 | 28 | 50 | |
| -Fold Error <3 (%) | 56 | 56 | 44 | 61 | |
| -Fold Error <4 (%) | 72 | 67 | 61 | 72 | |
| Median Predicted/Observed | 1.74 | 1.60 | 2.54 | 1.06 | |