Enzyme kinetic parameters for desethylamiodarone formation by rat liver microsomes from four individual rats, based on results of fit of eq. 2 to the data
Kinetic Parameter | Mean ± S.D. (Range) |
|---|---|
| km (μM) | 43.5 ± 32.1 (24.3-70.2) |
| Vmax (pmol/min/mg protein) | 370 ± 78.4 (250-463) |
| CLint (μl/min/mg protein) | 9.51 ± 3.42 (4.74-12.8) |