TABLE 1

Noncumulative percentage of dose excreted following a single oral dose of [14C]ruboxistaurin in female beagle dogs, male CD-1 mice, and bile duct-cannulated male Fischer 344 rats

Values represent mean ± S.E.

Time
Dog
Mouse
Rat
Urine
Feces
Urine
Feces
Urine
Feces
Bile
0-24 h 0.74 ± 0.19 49.1 ± 19.7 2.48 ± 0.17 87.79 ± 1.73 2.75 ± 0.62 26.69 ± 2.98 56.90 ± 1.71
24-48 h 0.31 ± 0.07 30.8 ± 17.5 0.03 ± 0.01 0.46 ± 0.02 0.14 ± 0.04 7.78 ± 2.43 2.18 ± 0.38
48-72 h 0.12 ± 0.02 6.9 ± 3.1 0.01 ± 0.00 0.08 ± 0.01 N.A. N.A. N.A.
72-96 h 0.06 ± 0.01 2.35 ± 1.46 N.A. N.A. N.A. N.A. N.A.
96-120 h 0.03 ± 0.01 0.71 ± 0.41 N.A. N.A. N.A. N.A. N.A.
Matrix total 1.25 ± 0.27 89.9 ± 0.6 2.52 ± 0.17 88.33 ± 1.73 2.86 ± 0.63 34.47 ± 0.87 59.08 ± 1.56
Total percentage recoverya
92.0 ± 0.6
91.4 ± 1.8
100.9 ± 1.5

  • N.A., not applicable.

  • ↵ a For dog, total percentage recovery includes the cage wash, and for mice and rats, it includes the cage wash and the carcass.