Percentage radioactivity of ruboxistaurin and its metabolites in plasma at 2, 4, 8, 16, 24, and 48 h postdose following a single oral administration of 10 mg/kg [14C]ruboxistaurin in female beagle dogs
Values represent mean ± S.E.
Metabolite | Mean Percentage Radioactivity | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 2 h | 4 h | 8 h | 16 h | 24 h | 48 h | ||||||
| Ruboxistaurin | 20.0 ± 1.4 | 9.9 ± 1.9 | 10.5 ± 1.8 | 15.0 ± 4.8 | 6.4 ± 1.3 | 3.4 ± 1.4 | |||||
| 1 | 59.4 ± 3.8 | 45.9 ± 14.3 | 20.2 ± 5.0 | 39.1 ± 2.3 | 40.6 ± 14.3 | 15.4 ± 8.7 | |||||
| 2 | 1.0 ± 0.1 | 1.1 ± 0.2 | 2.1 ± 0.9 | 1.6 ± 0.7 | 0.6 ± 0.4 | 1.5 ± 0.4 | |||||
| 3 | 3.4 ± 0.3 | 2.3 ± 0.4 | 2.6 ± 0.6 | 1.6 ± 0.2 | 0.8 ± 0.5 | 1.5 ± 0.6 | |||||
| 5 | 0.9 ± 0.1 | 1.4 ± 0.7 | 2.1 ± 0.7 | 1.4 ± 0.3 | 0.5 ± 0.4 | 1.3 ± 0.6 | |||||
|
6
| N.Q. | 0.3 ± 0.3 | 2.4 ± 1.7 | 1.3 ± 1.1 | 4.2 ± 1.9 | 7.4 ± 4.6 | |||||
N.Q., not quantifiable.