Pharmacokinetic parameters of S4 and M1 in dogs (n = 3)
Parameter | Unit | Mean ± S.D. |
|---|---|---|
| S4 | ||
| Vd1 | ml | 423 ± 49 |
| k10 | min-1 | 0.046 ± 0.017 |
| t1/2 | min | 125 ± 25 |
| ClS4 | ml/min | 41.3 ± 8.0 |
| AUCS4 | μg · min/ml | 2227 ± 377 |
| kh | min-1 | 0.0039 ± 0.0009 |
| M1 | ||
| Vd1′ | ml | 644 ± 171 |
| km | min-1 | 0.090 ± 0.035 |
| t1/2 | min | 118 ± 25 |
| ClM1 | ml/min | 54.5 ± 8.3 |
| AUCM1 | μg · min/ml | 894 ± 205 |
| fm |
| 0.53 ± 0.08 |