Mean (S.D.) pharmacokinetic parameters for the disposition of MPA, MPAGe, and MPAGa in the isolated perfused rat liver
Control Rats | TR- Rats | MPA-CsA Rats | |
|---|---|---|---|
| MPA AUC (mg · min/l) | 55.5 (14.1) | 112.8 (77.3) | 51.6 (6.2) |
| MPA CL (l/min) | 0.029 (0.007) | 0.018 (0.008)* | 0.029 (0.003) |
| MPA EH | 0.95 (0.3) | 0.59 (0.3)* | 0.98 (0.1) |
| MPA t1/2 (min) | 10.1 (2.4) | 19.5 (10.3)* | 9.7 (1.5) |
| MPAGe t1/2 bile (min) | 15.5 (1.1) | N.D. | 14.1 (1.4) |
| MPAGa t1/2 bile (min) | 20.9 (7.3) | N.D. | 16.2 (2.2) |
| CLMPA→MPAGe (ml/min) | 24 (7) | 11 (6)** | 20 (2) |
| CLMPA→MPAGa (ml/min) | 0.9 (0.4) | 0.2 (0.1)** | 0.5 (0.1)* |
N.D., not determined because of low concentrations in bile.
↵* p < 0.05 compared to controls. ** p < 0.01 compared to controls.