Mean (S.D.) percentage dose recovery
Control | TR- | MPA-CsA | |
|---|---|---|---|
| Total | 89.5 | 67.7** | 72.6* |
| (9.2) | (11.9) | (3.1) | |
| Liver | |||
| MPA | 1.17 | 4.41** | 1.08 |
| (0.99) | (0.41) | (0.47) | |
| MPAGe | N.D. | N.D. | N.D. |
| MPAGa | N.D. | N.D. | N.D. |
| Bile | |||
| MPA | 0.84 | 0.12 | 0.38 |
| (0.57) | (0.10) | (0.22) | |
| MPAGe | 84.0 | 0.6** | 69.3** |
| (8.7) | (0.4) | (2.5) | |
| MPAGa | 3.9 | 1.1** | 1.8* |
| (1.7) | (0.6) | (0.6) | |
| Perfusate | |||
| MPA | N.D. | 2.3 | N.D. |
| (5.5) | |||
| MPAGe | N.D. | 59.3** | N.D. |
| (12.2) | |||
| MPAGa | N.D. | N.D. | N.D. |
N.D., not detected.
↵* p < 0.05 compared to controls. ** p < 0.01 compared to controls.