TABLE 1

Historic or projected clinical PK parameters of compounds that were assessed preclinically for microdosing

Compound	Dose Regimen	Bioavailability	CL_p	Vd_ss	t_1/2	Reference
	mg	%	l/h/kg	l/kg	h
Fluconazole	400, q.d.	>90	0.016	0.6	32	Debruyne and Ryckelynck (1993)
Tolbutamide	500, b.i.d.	93	0.014	0.1	6	Balant (1981)
MLNX	500, b.i.d.^a	>90^a	0.42^a	∼1^a	2^a