Dose proportionality test using power model
Compound | Dose Range | Parameter | R2 | Slope | 95% Lower CI | 95% Upper CI | Inference |
|---|---|---|---|---|---|---|---|
| mg/kg | |||||||
| Tolbutamide | 0.001-1 | C max | 0.987 | 0.96 | 0.89 | 1.02 | Lineara |
| AUCinf | 0.980 | 0.92 | 0.84 | 1.00 | Linear | ||
| t 1/2 | 0.058 | 0.02 | -0.03 | 0.08 | Dose-independent | ||
| Fluconazole | 0.001-5 | C max | 0.984 | 0.96 | 0.91 | 1.01 | Linear |
| AUCinf | 0.984 | 0.96 | 0.90 | 1.01 | Linear | ||
| t 1/2 | 0.069 | -0.02 | -0.09 | 0.04 | Dose-independent | ||
| MLNX | 0.01-10 | C max | 0.985 | 1.09 | 1.01 | 1.17 | Nonlinear |
| AUCinf | 0.981 | 1.18 | 1.08 | 1.29 | Nonlinear | ||
| t 1/2 | 0.012 | -0.01 | -0.08 | 0.06 | Dose-independent | ||
| 0.01-1 | C max | 0.966 | 1.03 | 0.87 | 1.19 | Linear | |
| AUCinf | 0.976 | 1.02 | 0.89 | 1.15 | Linear | ||
|
|
|
t
1/2
| 0.009 | -0.02 | -0.15 | 0.12 | Dose-independent |
CI, confidence interval.
↵ a The system was considered to be linear when R2 ∼1, CIlower ≥0.8, and CIupper ≤1.25.