TABLE 1

Effect of DHA coadministration on the pharmacokinetic parameters of CsA after oral administration of CsA (5 mg/kg) to rats

Data are expressed as mean ± S.D.

Parameters
Control (without DHA) (n = 16)
Oral Dose of DHA
50 μg/kg (n = 6)
100 μg/kg (n = 7)
200 μg/kg (n = 7)
AUC∞ (mg/l · h) 9.78 ± 5.32 13.4 ± 5.78 22.41 ± 7.40** 23.41 ± 6.55**
t1/2 (h) 7.68 ± 1.04 8.00 ± 0.96 8.30 ± 1.65 8.52 ± 0.68
CLtot/F (l/h/kg) 0.748 ± 0.598 0.456 ± 0.271 0.248 ± 0.093* 0.230 ± 0.070*
Vdss/F (l/kg)
8.61 ± 6.34
5.57 ± 2.86
3.20 ± 0.85*
3.14 ± 0.86*

  • ↵* Statistically different from the corresponding value in the control group (p < 0.05).

  • ↵** Statistically different from the corresponding value in the control group (p < 0.01).