TABLE 2

Kinetic parameters for absorption of PL and isovaleryl-PL in rat jejunal single-pass perfusion

Values represent mean ± S.D. (n = 3).


Input Rate of Compounds



Absorption Rate (v1)

Disappearance Rate (v2)

Secretion Rate (v3)

CLappa

Peff b

CLdegc
nmol/min μl/min ×10-3 cm/min μl/min
PL
92.0 ± 4.67 nmol/min PL 6.19 ± 0.31 7.01 ± 0.51 21.6 ± 0.16 2.20 ± 0.16
Isovaleryl-PL Isovaleryl-PL 0.49 ± 0.14 50.5 ± 1.95 2.42 ± 0.79 16.6 ± 1.26 141 ± 20.5
92.9 ± 8.23 nmol/mind PL 7.20 ± 1.05 43.2 ± 3.49

IVA
23.7 ± 6.47

8.03 ± 2.74



  • a CLapp was calculated using eq. 4.

  • b Peff was calculated using eq. 6. The radius of segment was assumed to be 0.178 cm (Yamashita et al., 1997).

  • c CLdeg was calculated using eq. 5.

  • d Degradation of isovaleryl-PL was 1.5% and 8% of the initial concentration for 1 h in pH 6.5 luminal perfusate and pH 7.4 vascular perfusate, respectively.