TABLE 3

Variation between human livers in the inhibition of microsomal CYP3A4 activity by four furanocoumarin dimers Mean (±S.D. from triplicate experiments) IC50 values.

Liver
Inhibitor
88Prop
58Prop
88Octa
55EE
μM
HL7 0.026 ± 0.008 0.053 ± 0.007 0.021 ± 0.002 0.029 ± 0.008
HL12 0.012 ± 0.004 0.021 ± 0.005 0.021 ± 0.005 0.047 ± 0.007
HL21 0.017 ± 0.001 0.029 ± 0.005 0.029 ± 0.001 0.039 ± 0.012
HL25 0.035 ± 0.009 0.054 ± 0.002 0.076 ± 0.001 0.084 ± 0.002
HL31 0.055 ± 0.017 0.019 ± 0.005 0.037 ± 0.009 0.051 ± 0.004
Mean
0.029 ± 0.017
0.035 ± 0.017
0.037 ± 0.023
0.050 ± 0.021